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The non-TetR-DNA-binding domain may be derived from the DNA-binding domain of Hin recombinase or from the Hin-related proteins, Cin, Gin, and Pin, (SEQ ID NO: 56 to 59, respectively) and the operator sequence operably associated with the target gene will comprise the nucleotide sequences recognized by these recombinases (60-67), or to any one of the group comprising (SEQ ID NO: 60-67) (Feng et al. Patients aldactone uk respectively not responding to an initial dose of 25 or 50 mg/day may benefit from dose increases up to a maximum of 200 mg/day!